L45F (p.Leu45Phe) variant of TRAF6 (TNF receptor-associated factor 6)
L45F (p.Leu45Phe) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
L45F (p.Leu45Phe) variant details
- p.Leu45Phe
- ExAC rs759449231
- gnomAD rs759449231
- Missense
- Variant Prioritization Score for Impact Estimate 0.349
- REVEL 0.25
- MetaLR 0.37
- MetaSVM -0.47
- CADD 21.10
- PolyPhen-2 0.36
- SIFT 0.71
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available