L140F (p.Leu140Phe) variant of TRAF6 (TNF receptor-associated factor 6)
L140F (p.Leu140Phe) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L140F (p.Leu140Phe) variant details
- p.Leu140Phe
- ExAC rs757037041
- gnomAD rs757037041
- Missense
- Variant Prioritization Score for Impact Estimate 0.264
- REVEL 0.02
- MetaLR 0.05
- MetaSVM -1.00
- CADD 13.00
- PolyPhen-2 0.01
- SIFT 0.69
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available