K133I (p.Lys133Ile) variant of TRAF6 (TNF receptor-associated factor 6)
K133I (p.Lys133Ile) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
K133I (p.Lys133Ile) variant details
- p.Lys133Ile
- ExAC rs750341857
- gnomAD rs750341857
- Missense
- Variant Prioritization Score for Impact Estimate 0.23
- REVEL 0.18
- MetaLR 0.08
- MetaSVM -1.05
- CADD 22.40
- PolyPhen-2 0.19
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available