I174T (p.Ile174Thr) variant of TRAF6 (TNF receptor-associated factor 6)
I174T (p.Ile174Thr) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, published literature, and structural context.
I174T (p.Ile174Thr) variant details
- p.Ile174Thr
- gnomAD 11-36497193-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.13
- MetaLR 0.05
- MetaSVM -1.02
- CADD 18.20
- PolyPhen-2 0.15
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available