H154R (p.His154Arg) variant of TRAF6 (TNF receptor-associated factor 6)
H154R (p.His154Arg) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
H154R (p.His154Arg) variant details
- p.His154Arg
- gnomAD 11-36497253-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.152
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.04
- CADD 13.60
- PolyPhen-2 0.00
- SIFT 0.45
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available
- Literature evidence available