G43R (p.Gly43Arg) variant of TRAF6 (TNF receptor-associated factor 6)
G43R (p.Gly43Arg) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
G43R (p.Gly43Arg) variant details
- p.Gly43Arg
- ExAC rs753791639
- TOPMed rs753791639
- gnomAD rs753791639
- Missense
- Variant Prioritization Score for Impact Estimate 0.441
- REVEL 0.39
- MetaLR 0.54
- MetaSVM -0.15
- CADD 21.50
- PolyPhen-2 0.30
- SIFT 0.06
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available