G43E (p.Gly43Glu) variant of TRAF6 (TNF receptor-associated factor 6)
G43E (p.Gly43Glu) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
G43E (p.Gly43Glu) variant details
- p.Gly43Glu
- TOPMed rs1859713476
- Missense
- Variant Prioritization Score for Impact Estimate 0.409
- REVEL 0.39
- MetaLR 0.41
- MetaSVM -0.46
- CADD 19.30
- PolyPhen-2 0.02
- SIFT 0.15
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available