E137K (p.Glu137Lys) variant of TRAF6 (TNF receptor-associated factor 6)
E137K (p.Glu137Lys) in TRAF6 (TNF receptor-associated factor 6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
E137K (p.Glu137Lys) variant details
- p.Glu137Lys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.18
- REVEL 0.04
- MetaLR 0.03
- MetaSVM -0.97
- CADD 17.30
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available