E110K (p.Glu110Lys) variant of TRAF6 (TNF receptor-associated factor 6)
E110K (p.Glu110Lys) in TRAF6 (TNF receptor-associated factor 6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
E110K (p.Glu110Lys) variant details
- p.Glu110Lys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.553
- REVEL 0.48
- MetaLR 0.37
- MetaSVM -0.52
- CADD 23.30
- PolyPhen-2 0.17
- SIFT 0.14
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available