D161N (p.Asp161Asn) variant of TRAF6 (TNF receptor-associated factor 6)
D161N (p.Asp161Asn) in TRAF6 (TNF receptor-associated factor 6) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
D161N (p.Asp161Asn) variant details
- p.Asp161Asn
- rs950811873
- ClinGen CA220593563
- ClinVar RCV004471139
- TOPMed rs950811873
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.179
- REVEL 0.05
- MetaLR 0.02
- MetaSVM -0.96
- CADD 18.90
- PolyPhen-2 0.00
- SIFT 0.50
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 4.9e-05)
- Structural context available