A158G (p.Ala158Gly) variant of TRAF6 (TNF receptor-associated factor 6)
A158G (p.Ala158Gly) in TRAF6 (TNF receptor-associated factor 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
A158G (p.Ala158Gly) variant details
- p.Ala158Gly
- gnomAD 11-36497241-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.352
- REVEL 0.12
- MetaLR 0.10
- MetaSVM -1.04
- CADD 22.70
- PolyPhen-2 0.06
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available