V424L (p.Val424Leu) variant of TRAF3IP2 (E3 ubiquitin ligase TRAF3IP2)
V424L (p.Val424Leu) in TRAF3IP2 (E3 ubiquitin ligase TRAF3IP2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, published literature, and structural context.
V424L (p.Val424Leu) variant details
- p.Val424Leu
- gnomAD 6-111572930-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.487
- REVEL 0.28
- CADD 23.80
- PolyPhen-2 0.98
- SIFT 0.09
- Population evidence available
- Structural context available
- Literature evidence available