I453T (p.Ile453Thr) variant of TRAF3IP2 (E3 ubiquitin ligase TRAF3IP2)
I453T (p.Ile453Thr) in TRAF3IP2 (E3 ubiquitin ligase TRAF3IP2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data, published literature, and structural context.
I453T (p.Ile453Thr) variant details
- p.Ile453Thr
- gnomAD 6-111566547-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.69
- REVEL 0.79
- CADD 28.00
- PolyPhen-2 0.84
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available