I442V (p.Ile442Val) variant of TRAF3IP2 (E3 ubiquitin ligase TRAF3IP2)
I442V (p.Ile442Val) in TRAF3IP2 (E3 ubiquitin ligase TRAF3IP2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
I442V (p.Ile442Val) variant details
- p.Ile442Val
- rs375272521
- cosmic curated COSV60676
- ESP rs375272521
- ExAC rs375272521
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.348
- AlphaMissense 0.33
- MetaLR 0.03
- MetaSVM -1.08
- PolyPhen-2 0.88
- SIFT 0.10
- EVE 0.49
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available