Y39C (p.Tyr39Cys) variant of TRAF3 (TNF receptor-associated factor 3)
Y39C (p.Tyr39Cys) in TRAF3 (TNF receptor-associated factor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes structural context.
Y39C (p.Tyr39Cys) variant details
- p.Tyr39Cys
- rs147686384
- cosmic curated COSV61025
- ESP rs147686384
- TOPMed rs147686384
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.384
- AlphaMissense 0.82
- MetaLR 0.27
- MetaSVM -0.54
- PolyPhen-2 1.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available