S82I (p.Ser82Ile) variant of TRAF3 (TNF receptor-associated factor 3)
S82I (p.Ser82Ile) in TRAF3 (TNF receptor-associated factor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
S82I (p.Ser82Ile) variant details
- p.Ser82Ile
- rs1235290905
- NCI-TCGA Cosmic COSV1006
- cosmic curated COSV10069
- gnomAD rs1235290905
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.525
- REVEL 0.39
- MetaLR 0.37
- MetaSVM -0.35
- CADD 32.00
- PolyPhen-2 0.01
- SIFT 0.15
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available