S4I (p.Ser4Ile) variant of TRAF3 (TNF receptor-associated factor 3)
S4I (p.Ser4Ile) in TRAF3 (TNF receptor-associated factor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
S4I (p.Ser4Ile) variant details
- p.Ser4Ile
- gnomAD rs1369830104
- Missense
- Variant Prioritization Score for Impact Estimate 0.305
- REVEL 0.18
- MetaLR 0.12
- MetaSVM -0.92
- CADD 21.80
- PolyPhen-2 0.26
- SIFT 0.04
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available