S3L (p.Ser3Leu) variant of TRAF3 (TNF receptor-associated factor 3)
S3L (p.Ser3Leu) in TRAF3 (TNF receptor-associated factor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
S3L (p.Ser3Leu) variant details
- p.Ser3Leu
- rs1052600602
- NCI-TCGA Cosmic COSV6102
- cosmic curated COSV61027
- TOPMed rs1052600602
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.35
- REVEL 0.14
- MetaLR 0.11
- MetaSVM -0.87
- CADD 19.90
- PolyPhen-2 0.01
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 6e-05)
- Structural context available