S26R (p.Ser26Arg) variant of TRAF3 (TNF receptor-associated factor 3)
S26R (p.Ser26Arg) in TRAF3 (TNF receptor-associated factor 3) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Herpes simplex encephalitis, susceptibility to, 3; not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
S26R (p.Ser26Arg) variant details
- p.Ser26Arg
- rs375545964
- ClinGen CA7359152
- ClinVar RCV004336076
- ClinVar RCV006616849
- Uncertain significance
- Herpes simplex encephalitis, susceptibility to, 3; not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0836
- REVEL 0.05
- MetaLR 0.08
- MetaSVM -0.98
- CADD 0.81
- PolyPhen-2 0.01
- SIFT 0.04
- ClinVar: Uncertain significance (Herpes simplex encephalitis, susceptibility to, 3; not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available