E74D (p.Glu74Asp) variant of TRAF3 (TNF receptor-associated factor 3)
E74D (p.Glu74Asp) in TRAF3 (TNF receptor-associated factor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
E74D (p.Glu74Asp) variant details
- p.Glu74Asp
- ExAC rs765509930
- TOPMed rs765509930
- gnomAD rs765509930
- Missense
- Variant Prioritization Score for Impact Estimate 0.215
- REVEL 0.12
- MetaLR 0.19
- MetaSVM -1.02
- CADD 19.60
- PolyPhen-2 0.03
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available