E67D (p.Glu67Asp) variant of TRAF3 (TNF receptor-associated factor 3)
E67D (p.Glu67Asp) in TRAF3 (TNF receptor-associated factor 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
E67D (p.Glu67Asp) variant details
- p.Glu67Asp
- NCI-TCGA Cosmic COSV1006
- cosmic curated COSV10069
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.388
- REVEL 0.36
- MetaLR 0.28
- MetaSVM -0.65
- CADD 23.00
- PolyPhen-2 0.69
- SIFT 0.31
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available