E35K (p.Glu35Lys) variant of TRAF3 (TNF receptor-associated factor 3)
E35K (p.Glu35Lys) in TRAF3 (TNF receptor-associated factor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
E35K (p.Glu35Lys) variant details
- p.Glu35Lys
- ExAC rs753068608
- gnomAD rs753068608
- Missense
- Variant Prioritization Score for Impact Estimate 0.346
- REVEL 0.18
- MetaLR 0.08
- MetaSVM -1.06
- CADD 22.40
- PolyPhen-2 0.09
- SIFT 0.65
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available