V50M (p.Val50Met) variant of TPO (Thyroid peroxidase)
V50M (p.Val50Met) in TPO (Thyroid peroxidase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data, published literature, and structural context.
V50M (p.Val50Met) variant details
- p.Val50Met
- gnomAD 3-184375550-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.785
- CADD 25.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available