T57I (p.Thr57Ile) variant of TPO (Thyroid peroxidase)
T57I (p.Thr57Ile) in TPO (Thyroid peroxidase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
T57I (p.Thr57Ile) variant details
- p.Thr57Ile
- rs779250490
- gnomAD 3-184375570-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- CADD 17.20
- PolyPhen-2 0.01
- SIFT 0.19
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available