S75Y (p.Ser75Tyr) variant of TPO (Thyroid peroxidase)
S75Y (p.Ser75Tyr) in TPO (Thyroid peroxidase) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
S75Y (p.Ser75Tyr) variant details
- p.Ser75Tyr
- NCI-TCGA Cosmic COSV6109
- NCI-TCGA Cosmic COSV6111
- cosmic curated COSV61113
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.491
- CADD 19.30
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available