L68H (p.Leu68His) variant of TPO (Thyroid peroxidase)
L68H (p.Leu68His) in TPO (Thyroid peroxidase) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data.
L68H (p.Leu68His) variant details
- p.Leu68His
- rs1338916377
- NCI-TCGA Cosmic COSV1002
- cosmic curated COSV10022
- gnomAD rs1338916377
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.346
- AlphaMissense 0.15
- MetaLR 0.16
- MetaSVM -0.89
- PolyPhen-2 0.97
- SIFT 0.16
- EVE 0.14
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available