A56T (p.Ala56Thr) variant of TPO (Thyroid peroxidase)
A56T (p.Ala56Thr) in TPO (Thyroid peroxidase) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
A56T (p.Ala56Thr) variant details
- p.Ala56Thr
- rs745582362
- NCI-TCGA Cosmic COSV6110
- cosmic curated COSV61100
- ExAC rs745582362
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.341
- AlphaMissense 0.44
- MetaLR 0.08
- MetaSVM -1.01
- PolyPhen-2 0.98
- SIFT 0.17
- EVE 0.24
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available