T4S (p.Thr4Ser) variant of TPMT (Thiopurine S-methyltransferase)
T4S (p.Thr4Ser) in TPMT (Thiopurine S-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
T4S (p.Thr4Ser) variant details
- p.Thr4Ser
- gnomAD rs1443281341
- Missense
- Variant Prioritization Score for Impact Estimate 0.152
- REVEL 0.21
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 0.74
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available