I91M (p.Ile91Met) variant of TPMT (Thiopurine S-methyltransferase)
I91M (p.Ile91Met) in TPMT (Thiopurine S-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
I91M (p.Ile91Met) variant details
- p.Ile91Met
- TOPMed rs1399023154
- gnomAD rs1399023154
- Missense
- Variant Prioritization Score for Impact Estimate 0.52
- REVEL 0.51
- CADD 24.30
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available