I10M (p.Ile10Met) variant of TPMT (Thiopurine S-methyltransferase)
I10M (p.Ile10Met) in TPMT (Thiopurine S-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
I10M (p.Ile10Met) variant details
- p.Ile10Met
- ESP rs200780293
- ExAC rs200780293
- TOPMed rs200780293
- gnomAD rs200780293
- Missense
- Variant Prioritization Score for Impact Estimate 0.172
- REVEL 0.23
- CADD 1.59
- PolyPhen-2 0.00
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available