F66I (p.Phe66Ile) variant of TPMT (Thiopurine S-methyltransferase)
F66I (p.Phe66Ile) in TPMT (Thiopurine S-methyltransferase) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
F66I (p.Phe66Ile) variant details
- p.Phe66Ile
- gnomAD rs1236222449
- Missense
- Variant Prioritization Score for Impact Estimate 0.561
- REVEL 0.50
- CADD 25.60
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available