W119C (p.Trp119Cys) variant of TOP2A (DNA topoisomerase 2-alpha)
W119C (p.Trp119Cys) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
W119C (p.Trp119Cys) variant details
- p.Trp119Cys
- Ensembl rs2143688073
- Missense
- Variant Prioritization Score for Impact Estimate 0.578
- REVEL 0.43
- CADD 28.10
- PolyPhen-2 0.49
- SIFT 0.04
- Most common in the South Asian population (allele frequency 1.5e-05)
- Structural context available