V68I (p.Val68Ile) variant of TOP2A (DNA topoisomerase 2-alpha)
V68I (p.Val68Ile) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
V68I (p.Val68Ile) variant details
- p.Val68Ile
- ExAC rs777879639
- TOPMed rs777879639
- gnomAD rs777879639
- Missense
- Variant Prioritization Score for Impact Estimate 0.105
- REVEL 0.10
- CADD 8.11
- PolyPhen-2 0.00
- SIFT 0.19
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available