V3L (p.Val3Leu) variant of TOP2A (DNA topoisomerase 2-alpha)
V3L (p.Val3Leu) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
V3L (p.Val3Leu) variant details
- p.Val3Leu
- TOPMed rs902922533
- gnomAD rs902922533
- Missense
- Variant Prioritization Score for Impact Estimate 0.19
- REVEL 0.04
- CADD 18.70
- PolyPhen-2 0.00
- SIFT 0.28
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available