V179L (p.Val179Leu) variant of TOP2A (DNA topoisomerase 2-alpha)
V179L (p.Val179Leu) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
V179L (p.Val179Leu) variant details
- p.Val179Leu
- Ensembl rs2143686831
- Missense
- Variant Prioritization Score for Impact Estimate 0.486
- REVEL 0.29
- CADD 23.20
- PolyPhen-2 0.51
- SIFT 0.10
- Population evidence available
- Structural context available