V158L (p.Val158Leu) variant of TOP2A (DNA topoisomerase 2-alpha)
V158L (p.Val158Leu) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
V158L (p.Val158Leu) variant details
- p.Val158Leu
- Ensembl rs2143687628
- Missense
- Variant Prioritization Score for Impact Estimate 0.449
- REVEL 0.24
- CADD 22.30
- PolyPhen-2 0.33
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.9e-06)
- Structural context available