V132F (p.Val132Phe) variant of TOP2A (DNA topoisomerase 2-alpha)
V132F (p.Val132Phe) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
V132F (p.Val132Phe) variant details
- p.Val132Phe
- TOPMed rs1012367614
- Missense
- Variant Prioritization Score for Impact Estimate 0.441
- REVEL 0.21
- CADD 23.70
- PolyPhen-2 0.87
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9.5e-07)
- Structural context available