V107I (p.Val107Ile) variant of TOP2A (DNA topoisomerase 2-alpha)
V107I (p.Val107Ile) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
V107I (p.Val107Ile) variant details
- p.Val107Ile
- TOPMed rs1335490488
- gnomAD rs1335490488
- Missense
- Variant Prioritization Score for Impact Estimate 0.232
- REVEL 0.06
- CADD 16.10
- PolyPhen-2 0.03
- SIFT 0.76
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available