T181P (p.Thr181Pro) variant of TOP2A (DNA topoisomerase 2-alpha)
T181P (p.Thr181Pro) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
T181P (p.Thr181Pro) variant details
- p.Thr181Pro
- ExAC rs774581970
- gnomAD rs774581970
- Missense
- Variant Prioritization Score for Impact Estimate 0.67
- REVEL 0.69
- CADD 26.40
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 2e-05)
- Structural context available