S149N (p.Ser149Asn) variant of TOP2A (DNA topoisomerase 2-alpha)
S149N (p.Ser149Asn) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
S149N (p.Ser149Asn) variant details
- p.Ser149Asn
- gnomAD rs2035350456
- Missense
- Variant Prioritization Score for Impact Estimate 0.534
- REVEL 0.38
- CADD 24.80
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available