R32I (p.Arg32Ile) variant of TOP2A (DNA topoisomerase 2-alpha)
R32I (p.Arg32Ile) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
R32I (p.Arg32Ile) variant details
- p.Arg32Ile
- rs963352942
- NCI-TCGA Cosmic COSV7073
- TOPMed rs963352942
- gnomAD rs963352942
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.21
- CADD 28.20
- PolyPhen-2 0.76
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available