R200G (p.Arg200Gly) variant of TOP2A (DNA topoisomerase 2-alpha)
R200G (p.Arg200Gly) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
R200G (p.Arg200Gly) variant details
- p.Arg200Gly
- TOPMed rs2035341542
- Missense
- Variant Prioritization Score for Impact Estimate 0.218
- REVEL 0.09
- CADD 22.20
- PolyPhen-2 0.01
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available