R162Q (p.Arg162Gln) variant of TOP2A (DNA topoisomerase 2-alpha)
R162Q (p.Arg162Gln) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
R162Q (p.Arg162Gln) variant details
- p.Arg162Gln
- Ensembl rs2143686955
- Missense
- Variant Prioritization Score for Impact Estimate 0.655
- REVEL 0.54
- CADD 28.50
- PolyPhen-2 0.98
- SIFT 0.00
- Population evidence available
- Structural context available