R162* (p.Arg162Ter) variant of TOP2A (DNA topoisomerase 2-alpha)
R162* (p.Arg162Ter) in TOP2A (DNA topoisomerase 2-alpha) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data and structural context.
R162* (p.Arg162Ter) variant details
- p.Arg162Ter
- NCI-TCGA Cosmic COSV7073
- Ensembl rs2035346422
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.683
- CADD 37.00
- UniProt: Variant assessed as somatic; high impact.
- Population evidence available
- Structural context available