R106T (p.Arg106Thr) variant of TOP2A (DNA topoisomerase 2-alpha)
R106T (p.Arg106Thr) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
R106T (p.Arg106Thr) variant details
- p.Arg106Thr
- TOPMed rs1380174914
- gnomAD rs1380174914
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- REVEL 0.18
- CADD 23.30
- PolyPhen-2 0.09
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available