R106K (p.Arg106Lys) variant of TOP2A (DNA topoisomerase 2-alpha)
R106K (p.Arg106Lys) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
R106K (p.Arg106Lys) variant details
- p.Arg106Lys
- TOPMed rs1380174914
- gnomAD rs1380174914
- Missense
- Variant Prioritization Score for Impact Estimate 0.248
- REVEL 0.12
- CADD 17.90
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the East Asian population (allele frequency 0.00018)
- Structural context available