Q39P (p.Gln39Pro) variant of TOP2A (DNA topoisomerase 2-alpha)
Q39P (p.Gln39Pro) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
Q39P (p.Gln39Pro) variant details
- p.Gln39Pro
- ExAC rs773891227
- TOPMed rs773891227
- gnomAD rs773891227
- Missense
- Variant Prioritization Score for Impact Estimate 0.458
- REVEL 0.31
- CADD 27.60
- PolyPhen-2 0.96
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available