P111L (p.Pro111Leu) variant of TOP2A (DNA topoisomerase 2-alpha)
P111L (p.Pro111Leu) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
P111L (p.Pro111Leu) variant details
- p.Pro111Leu
- TOPMed rs1347294511
- Missense
- Variant Prioritization Score for Impact Estimate 0.358
- REVEL 0.24
- CADD 25.00
- PolyPhen-2 0.01
- SIFT 0.03
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available