P100S (p.Pro100Ser) variant of TOP2A (DNA topoisomerase 2-alpha)
P100S (p.Pro100Ser) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
P100S (p.Pro100Ser) variant details
- p.Pro100Ser
- gnomAD rs1225618145
- Missense
- Variant Prioritization Score for Impact Estimate 0.322
- REVEL 0.10
- CADD 22.60
- PolyPhen-2 0.01
- SIFT 0.09
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available