N16S (p.Asn16Ser) variant of TOP2A (DNA topoisomerase 2-alpha)
N16S (p.Asn16Ser) in TOP2A (DNA topoisomerase 2-alpha) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
N16S (p.Asn16Ser) variant details
- p.Asn16Ser
- ExAC rs756092705
- gnomAD rs756092705
- Missense
- Variant Prioritization Score for Impact Estimate 0.084
- REVEL 0.05
- CADD 9.26
- PolyPhen-2 0.00
- SIFT 0.47
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available